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Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma
Purpose: To investigate the relationship between optic disc vessel density (ODVD) reduction and...
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Consider cotton wool spots as potential triggers for (non-glaucomatous) nerve fibre bundle defects
It may be tempting to make a glaucoma diagnosis in the presence of a nerve fibre bundle defect...
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Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition
Purpose: We tested the hypothesis that a questionnaire-based risk score predicts the prevalence...
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Not every ring scotoma is due to glaucoma
In advanced stages of glaucoma, patients may present with an annular scotoma, also known as ring...
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Relationship between Blood Pressure and Rates of Glaucomatous Visual Field Progression
Purpose: To examine the relationship between systemic arterial blood pressure (BP) and the rate...
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Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multi-Centred Study
Prcis: Deep sclerectomy (DS) and canaloplasty provide better intraocular pressure (IOP) control...
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Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study
Purpose: A cross-sectional pilot study to compare macular oxygen saturation (sO2) and associated...
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Childhood Glaucoma
SIG Corner Editor: Hana Abouzeid Chair: Esther Hoffmann Co-chair: Zeynep Aktas Childhood glaucoma...
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Avoid premature removal of the intraluminal suture in glaucoma drainage devices to minimize the risk of hypotony
While prolene suture removal is an effective method for reducing IOP at the slit-lamp, removing...
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Biomechanics-Function in Glaucoma: Improved Visual Field Predictions from IOP-Induced Neural Strains
Purpose: (1) To assess whether neural tissue structure and biomechanics could predict functional...
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Validation of a Visual Field Prediction Tool for Glaucoma: A Multicenter Study Involving Patients With Glaucoma in the United Kingdom
Purpose: A previously developed machine-learning approach with Kalman filtering technology...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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Retinal Nerve Fiber Layer Optical Texture Analysis
PURPOSE: To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate the prevalence, patterns, and risk factors of...
February 12, 2024
A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.
PURPOSE: Glaucoma represents a pressing public health need among African ancestry individuals. This study provides novel insight into the genetic...
January 15, 2024
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma
Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However,...
January 15, 2024
Identifying a high polygenic risk for glaucoma will allow us to identify glaucoma patients at risk for rapid structural and functional glaucoma progression
The Science behind the Tip The identification of an individual´s genetic risk of a disease is increasingly recognized as a tool in disease risk...
January 15, 2024
Selective Laser Trabeculoplasty can be considered lifesaving treatment for the cornea when severe ocular disease co-exists with glaucoma
The Science behind the Tip Elevated intraocular pressure (IOP) and glaucoma are not uncommon in cases of cicatricial conjunctivitis (CC) such as...
December 17, 2023
Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering
Significance The “in silico–in vitro–in vivo” funnel holds significant potential for identifying targets to control cellular processes in research...
December 17, 2023
Validating Trend-Based End Points for Neuroprotection Trials in Glaucoma
PURPOSE: The purpose of this study was to evaluate the power of trend-based visual field (VF) progression end points against long-term development...
December 17, 2023
Risk Factors for Failure in Glaucoma Patients undergoing Microshunt Implantantion
PURPOSE: Evaluate risk factors for failure of Microshunt in glaucoma patients. DESIGN: Multicenter retrospective cohort study. METHODS:250 eyes...
December 17, 2023
How Myopia and Glaucoma Influence the Biomechanical Susceptibility of the Optic Nerve Head
1Yong Loo Lin School of Medicine, National University of Singapore, Singapore 2Ophthalmic Engineering & Innovation Laboratory, Singapore Eye...
November 15, 2023
European Glaucoma Society research priorities for glaucoma care
Background/Aims: The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that...
November 15, 2023
Exfoliation (pseudoexfoliation) syndrome (XFS, with or without glaucoma) is associated with clinically significant non-vascular systemic diseases.
The Science behind the Tip Systemic vascular dysfunction in XFS patients and statistically significant associations of systemic diseases with XFS...
November 15, 2023
BIG DATA SIG
SIG Corner Editor: Hana Abou Zeid Chair: Ananth Viswanathan Co-chair: Marta Pazos Mission To understand the genetic causes of glaucoma and the...
October 15, 2023
Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
Author(s): Xikun Han 1,2,37 , Puya Gharahkhani 1,2,3,37, Andrew R. Hamel 4,5, Jue Sheng Ong 1, Miguel E. Rentería 2,3,6, Puja Mehta 4,5, Xianjun...
October 15, 2023
MERCURY‑3: a randomized comparison of netarsudil/latanoprost and bimatoprost/timolol in open‑angle glaucoma and ocular hypertension
Author(s): Ingeborg Stalmans1,2 · Kin Sheng Lim3 · Francesco Oddone4 · Marek Fichtl5,6 · Jose I. Belda7,8 · Anton Hommer9 · Guna Laganovska10 ·...
October 15, 2023
Consider sources of bias when using OCT angiography
The Science behind the Tip OCT angiography (OCTA) has gained great interest in glaucoma diagnosis (1, 2) and follow up(3). However, several...
October 15, 2023
Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer
Author(s): Ronen E Mukamel (1), Robert E Handsaker (2), Maxwell A Sherman (3), Alison R Barton (4), Margaux L A Hujoel (5), Steven A McCarroll (6),...
September 15, 2023
Long-term Impact of Immediate Versus Delayed Treatment of Early Glaucoma: Results From the Early Manifest Glaucoma Trial
PURPOSE: To compare long-term visual outcomes in the 2 arms of the Early Manifest Glaucoma Trial (EMGT) and determine if delayed treatment was...
September 15, 2023
OCT Imaging of glaucoma patients at 6-month intervals may enhance progression detection while reducing the healthcare burden of more frequent testing
The Science behind the Tip Thanks to its high reproducibility,1-3 OCT has become widely used for monitoring structural optic nerve changes in...
September 15, 2023
Intravitreal bevacizumab improves trabeculectomy survival at 12 months: the bevacizumab in trabeculectomy study-a randomised clinical trial
Author(s): John A Landers, Sean Mullany, Jamie E Craig 1 Ophthalmology, Flinders University of South Australia, Adelaide, South Australia,...
September 15, 2023
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Glaucoma control can be detrimentally affected by recurrent anti- VEGF treatment for macular degeneration or diabetic macular oedema
The Science behind the Tip Patients undergoing anti-VEGF (vascular endothelial growth factor) therapy for age-related macular degeneration or...
August 31, 2023
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...
July 30, 2023
Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...
July 30, 2023
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...
July 30, 2023
Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...
July 30, 2023
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Ligand-induced activation and G protein coupling of prostaglandin F2α receptor
Author(s): Canrong Wu (1), Youwei Xu (2), Qian He (2), Dianrong Li (3), Jia Duan (2), Changyao Li (4,5), Chongzhao You (2), Han Chen (6), Weiliang...
June 30, 2023